Peptide Database

Peptide NameYFGAP-NH2(Yellowfin tuna GAPDH-related antimicrobial peptide; fish, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC154H258N48O40

DescriptionStandard

        VKVGINGFGRIGRLVTRAAFHGKKVEVVAIND
    

Molecular Weight3421.99 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)3.83

Net Charge (pH 7.4) 3.56

Charge Density (pH 7.0) 0.1195

GRAVY Index0.26

Hydrophobic Moment 0.92

Boman Index0.08

Instability Index-15.07

Aliphatic Index 112.50

Aromaticity 0.0625

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1438.87

LogP -13.14

H-bond Donors 51.0

H-bond Acceptors 45.0

Rotatable Bonds 117.0

Heavy Atoms 242.0

Ring Count 3.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0413712 VERIFIED: YES

Provenance & Taxonomy

OrganismThunnus albacares [Animal]

Tax ID8236.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial

TargetHuman erythrocytes

Activity25 μg/mL

MethodHemolysis

PaperSeo JK, Lee MJ, Go HJ, et al. Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares. Fish Shellfish Immunol. 2012 Oct;33(4):743-752. doi:10.1016/j.fsi.2012.06.023. PMID22771964 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22771964/

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