Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2437H3881N651O679S23

DescriptionStandard

        MREDMARGLHDAPRWAPLLVLIAVGTTVTAAANPGVVVRISRKGLDYASQQGTAALQKELKRIKIPDYSGSFKVKLLGKGRYSFYSMDIREFQLPSCQISMVPNVGLKFSISNANIKISGKWKARKRFVKTSGNFDLSVEGVSISADLKLGSNSTSGKPTVTCPSCSSHINSVHVRISKSRVGWLIRLFRKKIESTLRNKLNSQICEKVTSSVSSELQPYFQTLPVMTKIDAVAGINYGLVAPPTTTAETLDVQMKGEFYSQNHHNPPPFAPPVMEFPAAHDHMVYLGLSDYFFNTAGLVYQQAGVLKMTLRDDMIPKESKFRLTTKFFGNFLPEVAKMFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGMSTTGSMEVGAKSDRLVGKLKVDRLLLELKHSNIGPFPVELMQAIMNYIVPTFVLPRVNEKLQKGCPLPMPARVQLYNMVLQPHQNFLLFGADVIYK
    

Molecular Weight53901.33 Da

Isoelectric Point (pI)9.75

Net Charge (pH 7.0)23.42

Net Charge (pH 7.4) 22.47

Charge Density (pH 7.0) 0.0481

GRAVY Index-0.04

Hydrophobic Moment 0.78

Boman Index0.08

Instability Index36.15

Aliphatic Index 90.64

Aromaticity 0.0862

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0312256 VERIFIED: NO

Provenance & Taxonomy

OrganismColobus angolensis palliatus [Animal]

FamilyBPI/LBP

Tax ID336983

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria