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MYP_084898
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Basic Information
BacSP222 (bacteriocin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
50 amino acids
C276H418N74O68S
Standard
Sequence
MAGLLRFLLSKGRALYNWAKSHVGKVWEWLKSGATYEQIKEWIENALGWR
Physicochemical Analysis
5892.79 Da
9.87
3.59
3.31
0.0718
-0.30
0.58
0.06
9.21
91.80
0.1600
30480.00
30480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2312.50
-13.12
84.0
74.0
195.0
419.0
14.0
52.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0215193 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus pseudintermedius strain [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
No Cys, Pro, and Asp. N-terminal formylated. APD analysis reveals that the sequence of this plasmid-encoded bacteriocin shows 39% similarity to S. aureus Aureocin A53
Bio-Activity Profile
Antimicrobial Antifungal
S. intermedius ATCC 29663, S. intermedius R-2725
1.2-2 μM
MIC
PaperA peptide factor secreted by Staphylococcus pseudintermedius exhibits properties of both bacteriocins and virulence factors
RECORD: Rec_0218238 VERIFIED: YES
Provenance & Taxonomy
isolated from dog skin lesions,Staphylococcus pseudintermedius strain 222 [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial Cytotoxic Antimicrobial
PaperPubMed PMID: 26411997 PMID26411997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26411997/
RECORD: Rec_0233944 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus pseudintermedius strain [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
No Cys, Pro, and Asp. N-terminal formylated. APD analysis reveals that the sequence of this plasmid-encoded bacteriocin shows 39% similarity to S. aureus Aureocin A53
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus MRSA USA300 strain FPR3757, Staphylococcus aureus KB/8658, Staphylococcus aureus ATCC 25923
0.89-1.3 μM
MIC
PaperA peptide factor secreted by Staphylococcus pseudintermedius exhibits properties of both bacteriocins and virulence factors
RECORD: Rec_0237593 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 25923
PMID34200765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34200765/
RECORD: Rec_0254894 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus pseudintermedius [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Streptococcus sanguinis PCM 2335
3.50± 0.85 μM
MIC
PMID26411997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26411997/
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