Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2392H3807N617O661S14

DescriptionStandard

        KGEKMLKTWYSFLLCCLSLRLEANPGLKVRITQKGLDYGSRIGMELLKQALLKETFPSWSGQESFSVVKVNYVISRLRINAVDFPETSASFIPGTGVSLSVAHASATISADWRMNTWLLKDQGGITVSISGLFIAVIFKVSRDSTGRLSILLHNCQLSINSLKVKLNGGSSWIYSFLSGYLEKPIHTKLDKNLCLNIKYKVQLMDAQLKKHKVLSQIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGSHTEPPFVPAPFDFPNQGDSMLYLGVSSYFIKSASLAYYRAGVFNITISKELATTFNLNTALFKDFVPEIALSYVTACPVLLKLMATSPPAVSLNADRCILQITGCVEVFAVLPNSTTQYIFRGNLTASTRGNLTITKRKLIISLLLKRFQFSLLHSILGFSEISLVENFLSYALRSAVIPVINDKLGKGFPLLNLAHTTLTRPVIRMNQGHLVISTNVHYK
    

Molecular Weight52233.46 Da

Isoelectric Point (pI)9.63

Net Charge (pH 7.0)21.57

Net Charge (pH 7.4) 20.65

Charge Density (pH 7.0) 0.0457

GRAVY Index0.23

Hydrophobic Moment 0.66

Boman Index0.15

Instability Index28.86

Aliphatic Index 108.83

Aromaticity 0.0975

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0119143 VERIFIED: NO

Provenance & Taxonomy

OrganismHaliaeetus albicilla [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria