Peptide Database

Peptide NameTumor necrosis factor, soluble form

Function Ontology

Anticancer

Anticancer ▸ tumor necrosis factor family

Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide

Immunology ▸ Immune modulation ▸ Cytokine modulation

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length157 amino acids

Chemical FormulaC778H1227N215O231S2

DescriptionStandard

        VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
    

Molecular Weight17352.50 Da

Isoelectric Point (pI)7.00

Net Charge (pH 7.0)-0.00

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0000

GRAVY Index-0.21

Hydrophobic Moment 0.66

Boman Index0.04

Instability Index33.17

Aliphatic Index 96.88

Aromaticity 0.0828

Extinction Coeff. Reduced 21430.00

Extinction Coeff. Oxidized 21555.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7163.87

LogP -71.03

H-bond Donors 246.0

H-bond Acceptors 236.0

Rotatable Bonds 565.0

Heavy Atoms 1226.0

Ring Count 28.0

Amide Bonds 173.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0320452 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Familytumor necrosis factor family

Tax ID9606; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide69-101

Bio-Activity Profile

Function

Cytokine Growth factor tumor necrosis factor family Chemokine-like Host defense

RECORD: Rec_0384303 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyInterleukin

Tax ID32630

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Coagulation factor replacement Enzyme replacement

Half-LifeTasonermin has a terminal half life of 20-30 min at doses of 150 µg/m² [L1339]. This value increases as dosage increases.