Peptide Database

Peptide NameSLAY-screened peptide P549

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC88H143N37O26

DescriptionStandard

        LHNADHRAADHRTISRHK
    

Molecular Weight2135.31 Da

Isoelectric Point (pI)10.74

Net Charge (pH 7.0)2.11

Net Charge (pH 7.4) 1.70

Charge Density (pH 7.0) 0.1172

GRAVY Index-1.58

Hydrophobic Moment 0.44

Boman Index-0.51

Instability Index47.72

Aliphatic Index 60.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1042.61

LogP -13.23

H-bond Donors 38.0

H-bond Acceptors 32.0

Rotatable Bonds 71.0

Heavy Atoms 151.0

Ring Count 4.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0071604 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/