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MYP_084668
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Basic Information
Dybowskin-3 , Brevinin-2DYc
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C147H254N40O42S2
Standard
Sequence
GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC
Physicochemical Analysis
3317.96 Da
9.24
2.74
2.50
0.0830
0.47
0.64
0.19
4.13
117.88
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1325.86
-12.88
47.0
47.0
118.0
231.0
1.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0229525 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli KCTC2433
15 μg/mL
MIC
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0245017 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Proteus mirabilis
100 μg/mL
MIC
PMID17698251;17688900 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0250173 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus KCTC3881
50 μg/mL
MIC
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0272893 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
cancer cells MCF7 cells and Hela cells
~50 μM
IC50
PaperPurification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii
RECORD: Rec_0272993 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus ATCC4698
39 μg/mL
MIC
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
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