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MYP_084668
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Basic Information
Dybowskin-3 , Brevinin-2DYc
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
33 amino acids
C147H254N40O42S2
Standard
Sequence
GLFDVVKGVLKGVGKNVAGSLLEQLKCKLSGGC
Physicochemical Analysis
3317.96 Da
9.24
2.74
2.50
0.0830
0.47
0.64
0.19
4.13
117.88
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1325.86
-12.88
47.0
47.0
118.0
231.0
1.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0118342 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
15 μM
MIC
RECORD: Rec_0123763 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
hRBC
100 μg/mL
Hemolysis
PMID17698251;17688900 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0125625 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0152190 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
PaperS.S. Kim et al. / Peptides 28 (2007) 1532-1539. Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii Evidence URLhttps://www.uniprot.org/uniprotkb/P0C5X3/entry
RECORD: Rec_0155018 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
100 μg/mL
MIC
PMID17698251;17688900 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
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