Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length404 amino acids

Chemical FormulaC2078H3235N533O585S16

DescriptionStandard

        MWILRWMCWLSLLLSGHCGPGVMMRVSQKWLDYVRSEGTEVLRHMLLKDPLPDITGFTHMFGKVNYTISKVLIEEFDVPHTYAVPSPPTNVKFLVEDAKTKVFGQWKVKHWLVNDNGDFNLRLSGVSIAAVIRTFKDSSGRPSVLLSACHSEVKNAKVHLSGGASWLYNLFTVFLEKPIRNSVNEKLCPRVNEAVSILQRELATFHATSRLDAKHEIDYSLINPPQVEETYIDLDLKGSVHPIGLSQYDNPPDIHIDLPNGRASMIYVGLTEYFFNSLAKNYFNSGVLKISLTHEQFPHAFWLRTEGYVTIIPKIKSYYPTSQAMELILTATKAPVVTLTPHNIILEMTGSLQGMAIMPYLITNEIFSVDMTATLISDKVHLSDLNLEVSFVSESRIPASSVFI
    

Molecular Weight45557.17 Da

Isoelectric Point (pI)6.57

Net Charge (pH 7.0)-2.19

Net Charge (pH 7.4) -3.32

Charge Density (pH 7.0) -0.0054

GRAVY Index0.04

Hydrophobic Moment 0.76

Boman Index0.13

Instability Index41.02

Aliphatic Index 99.83

Aromaticity 0.0990

Extinction Coeff. Reduced 64860.00

Extinction Coeff. Oxidized 65110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0253672 VERIFIED: NO

Provenance & Taxonomy

OrganismLeptobrachium leishanense [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence