Peptide Database

Peptide NameBradykinin-potentiating peptide B

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC56H94N16O13

DescriptionStandard

        QGLPPRPKIPP
    

Molecular Weight1199.44 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.1599

GRAVY Index-1.09

Hydrophobic Moment 0.11

Boman Index-0.12

Instability Index61.94

Aliphatic Index 70.91

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 441.38

LogP -2.84

H-bond Donors 12.0

H-bond Acceptors 15.0

Rotatable Bonds 31.0

Heavy Atoms 85.0

Ring Count 5.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084306 VERIFIED: YES

Provenance & Taxonomy

OrganismGloydius blomhoffii [Animal]

FamilyBradykinin-potentiating peptide

Tax ID242054

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation ACE inhibitory

Targetrabbit lung angiotensin-converting enzyme

Activity15 μM

MethodIC50

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0236373 VERIFIED: YES

Provenance & Taxonomy

OrganismGloydius blomhoffii [Animal]

FamilyBradykinin-potentiating peptide

Tax ID242054

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation ACE inhibitory

Targetrat gastric fundus smooth muscle

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0398292 VERIFIED: YES

Provenance & Taxonomy

OrganismGloydius blomhoffii [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Bio-Activity Profile

Function

Toxin Venom