Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length491 amino acids

Chemical FormulaC2432H3896N652O682S17

DescriptionStandard

        MARGADNTLRWATLVALAALGTAVTAAANPGIVARITQKGLDYACQQGVATLRKELEKITIPTFSGSFKIKYFGKGRYNFYSKASGNFDLSVEGISVLASLRLGYDPTSGHSTVSCSSCRSHINRVHVRTSGSSLKWLIQLFHRNIESALRKAMESKICKMLTNTVSSKLQPYFQTLPVTAKVDRMVGINYSLVAPPKATAENLDGLLKGEFFSLDHPSPPPFAPPALALPADHDRMVYLCISEYFFNTAGLVYQKAGVLNLTINNSMIPKKSLFSLTTNFFGTLIPKVSTMFPNMEMQFLIWASFPPHLTVHPSGLDLTFVLETQAFAVLPNASLAPLFRIEMNSSISVDIGVRSKRLIGELRLNKLLLELKHSNIGPFSVELLQAVMNFAVPTLVLPKINEKLQRGFPLPLPAYIQLSNLVLQPHQVSAQVSLAKSPTTVATFLHRSSMPSALQPSQKVGAVNNQRTKANTQKSTPLLNESKVKAKSLL
    

Molecular Weight53726.01 Da

Isoelectric Point (pI)9.89

Net Charge (pH 7.0)24.42

Net Charge (pH 7.4) 23.48

Charge Density (pH 7.0) 0.0497

GRAVY Index0.06

Hydrophobic Moment 0.81

Boman Index0.11

Instability Index36.84

Aliphatic Index 97.74

Aromaticity 0.0794

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0082335 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyBPI/LBP

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria