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MYP_084527
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Basic Information
Latarcin-4b
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
24 amino acids
C133H218N34O35S
Standard
Sequence
SLKDKVKSMGEKLKQYIQTWKAKF
Physicochemical Analysis
2885.43 Da
10.00
4.46
4.23
0.1857
-0.97
0.54
-0.24
-12.00
65.00
0.1250
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1172.25
-8.20
41.0
41.0
105.0
203.0
4.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0367954 VERIFIED: YES
Provenance & Taxonomy
Lachesana tarabaevi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli MH1
4.4 μM
MIC
PMID16735513 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16735513/
RECORD: Rec_0388855 VERIFIED: YES
Provenance & Taxonomy
Lachesana tarabaevi [Animal]
Latarcin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
P-aeruginosa
>35 μM
MIC
PaperLatarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. PMID16735513 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16735513/
RECORD: Rec_0398741 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 50.0%, E 0.0%, T 33.3%, C 16.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0420729 VERIFIED: YES
Provenance & Taxonomy
Lachesana tarabaevi [Animal]
Latarcin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0426710 VERIFIED: NO
Provenance & Taxonomy
Lachesana tarabaevi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Toxin
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