Peptide Database

Peptide NameGrowth/differentiation factor 8

Function Ontology

Antiviral

Binding / Molecular interaction ▸ Binding activity

Immunology ▸ Immune modulation ▸ Cytokine modulation

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity

Standard StatusStandard

Sequence Length109 amino acids

Chemical FormulaC550H823N147O158S12

DescriptionStandard

        DFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
    

Molecular Weight12407.09 Da

Isoelectric Point (pI)6.44

Net Charge (pH 7.0)-0.97

Net Charge (pH 7.4) -1.54

Charge Density (pH 7.0) -0.0089

GRAVY Index-0.33

Hydrophobic Moment 0.41

Boman Index0.02

Instability Index34.25

Aliphatic Index 58.17

Aromaticity 0.1284

Extinction Coeff. Reduced 19940.00

Extinction Coeff. Oxidized 20440.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4840.86

LogP -44.87

H-bond Donors 174.0

H-bond Acceptors 173.0

Rotatable Bonds 392.0

Heavy Atoms 867.0

Ring Count 28.0

Amide Bonds 115.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0074903 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyTGF-beta family

Tax ID9606; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-16; 15-74; 43-106; 47-108; 73-73

Bio-Activity Profile

Function

Cytokine Growth factor TGF-beta family Growth factor signaling Heparin-binding

RECORD: Rec_0414457 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyTGF-beta family

Tax ID10090; 0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide15-74; 43-106; 47-108

Bio-Activity Profile

Function

Cytokine Growth factor TGF-beta family Antiviral Growth factor signaling Heparin-binding Host defense