Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length41 amino acids

Chemical FormulaC223H337N59O76

DescriptionStandard

        EWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLW
    

Molecular Weight5060.41 Da

Isoelectric Point (pI)4.22

Net Charge (pH 7.0)-7.06

Net Charge (pH 7.4) -7.29

Charge Density (pH 7.0) -0.1721

GRAVY Index-1.18

Hydrophobic Moment 0.58

Boman Index-0.17

Instability Index54.94

Aliphatic Index 88.05

Aromaticity 0.0976

Extinction Coeff. Reduced 17990.00

Extinction Coeff. Oxidized 17990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2256.41

LogP -20.39

H-bond Donors 75.0

H-bond Acceptors 70.0

Rotatable Bonds 174.0

Heavy Atoms 358.0

Ring Count 8.0

Amide Bonds 48.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0385451 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 | CHO-WT cells; K652 cells

Activity0.0015±0.0001 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 30 min; E. coli: >10 h

PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation. | Danial M, van Dulmen TH, Aleksandrowicz J, Pötgens AJ, Klok HA. | Bioconjug Chem. 2012 Aug 15;23(8):1648-60. | DOI:10.1021/bc3002248 | PMID:22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/

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