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MYP_084453
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Basic Information
T-267
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
35 amino acids
C162H278N46O58S
Standard
Sequence
SLERLDVGTNLGNAIAKLEDAKELLESSDQILRSM
Physicochemical Analysis
3830.28 Da
4.44
-3.53
-3.75
-0.1008
-0.27
0.65
-0.06
35.79
117.14
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1720.08
-18.94
59.0
56.0
137.0
267.0
0.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006158 VERIFIED: YES
Provenance & Taxonomy
Measles morbillivirus [Virus]
Virus-derived peptide
11234;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor Cytoprotective
Measles virus; HEp-2 cells
12.3 μM
EC50 / Fusion inhibition
PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
RECORD: Rec_0085851 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
RECORD: Rec_0184244 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-MeV Entry inhibition
Measles virus; HEp-2 cells
3.211 μM
EC50 / Fusion inhibition
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91. | DOI:10.1073/pnas.93.5.2186 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
RECORD: Rec_0205030 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0209135 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/
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