Peptide Database

Peptide NameSLAY-screened peptide P2836

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC95H140N30O29S

DescriptionStandard

        PWCPASQINHFPNNRGATST
    

Molecular Weight2198.38 Da

Isoelectric Point (pI)8.68

Net Charge (pH 7.0)1.04

Net Charge (pH 7.4) 0.91

Charge Density (pH 7.0) 0.0518

GRAVY Index-0.87

Hydrophobic Moment 0.39

Boman Index-0.04

Instability Index32.91

Aliphatic Index 29.50

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 944.30

LogP -13.47

H-bond Donors 33.0

H-bond Acceptors 32.0

Rotatable Bonds 63.0

Heavy Atoms 155.0

Ring Count 7.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0132419 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/