Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length174 amino acids

Chemical FormulaC923H1404N226O244S6

DescriptionStandard

        PMNMDNATDKMLYFGVSEYLFNTAGFAYHSAGALNYLITNNLASFLIPKKSPFQLNTSSIGKLIPEVQKQYPNMLMEVRVLSNAPPAVIIQPKKTILSGYADILTFAILPNGSRAFLFLNHLRYFRLSTPFFNLLPVHSEFQYQYINIFPDPTPHPHLMYKNQFVSVLQAPSIL
    

Molecular Weight19762.78 Da

Isoelectric Point (pI)9.32

Net Charge (pH 7.0)4.39

Net Charge (pH 7.4) 4.05

Charge Density (pH 7.0) 0.0252

GRAVY Index0.09

Hydrophobic Moment 0.64

Boman Index0.19

Instability Index39.60

Aliphatic Index 96.44

Aromaticity 0.1379

Extinction Coeff. Reduced 14900.00

Extinction Coeff. Oxidized 14900.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7424.45

LogP -71.13

H-bond Donors 246.0

H-bond Acceptors 259.0

Rotatable Bonds 625.0

Heavy Atoms 1399.0

Ring Count 45.0

Amide Bonds 195.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0019845 VERIFIED: NO

Provenance & Taxonomy

OrganismEptatretus burgeri [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence