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MYP_084345
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Basic Information
Brevinin-1E-OG4 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
24 amino acids
C131H207N31O27S2
Standard
Sequence
FLPFLAGLAANFLPKLFCKITRKC
Physicochemical Analysis
2712.37 Da
9.85
3.74
3.50
0.1557
0.88
0.77
0.28
20.32
110.00
0.1667
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
918.32
-2.73
33.0
33.0
86.0
191.0
6.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0142558 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperAnti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. PMID: 17272268. PMID17272268 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
RECORD: Rec_0201568 VERIFIED: YES
Provenance & Taxonomy
Odorrana margaretae [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial
PaperJ.M. Conlon et al. / Peptides 27 (2006) 2111-2117. Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0298029 VERIFIED: YES
Provenance & Taxonomy
Odorrana margaretae [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0352770 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 58.3%, E 0.0%, T 25.0%, C 16.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0397830 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Brevinin
167935
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial
PaperJ.M. Conlon et al. / Peptides 27 (2006) 2111-2117. Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/