Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2398H3794N634O674S16

DescriptionStandard

        MAREPDKALTPATLVVLATLGTAAIATTNPGIVARITQKGLDYACQQGVAVLQKELEKITIPTFSGSFKIKHLGKGHYSFYSLAIRGFQLPSSQIKLAPSEGLDLSIADANVKISGKWKARKNFIKTSGNFDLSVEGVSISAVLELGFDPASGHCTVSCPRCNNHINGVRVHISGSSLGWLINLFHEKIESSLRNRMTSEICKVVTSSVSSKLQQYLETLPVTTRIDHVAGINYSLVAPPTATTDNLDGQLKGEFFRWAHPSPPPFAPPPLAFPSDHDRMVYLGISNYFFNTAGFVYQQAGVLNLTVTDNMIPKESKVRLTTEVFGILIPQVAKMFPNMKVQLVFWASSPPHLTMHPEGLVLTPTLDAQAFAVLPNSSLAPLFMLRLSMNISVTVGATPDRLVGQLRLNRLLLELKHSDIGPFSVEVLQAVMNYVVPIAVIPKVNERLQEGFPLPMPKNVQLFNLVLQSHQNFLLFGADVHYG
    

Molecular Weight52802.66 Da

Isoelectric Point (pI)9.04

Net Charge (pH 7.0)7.71

Net Charge (pH 7.4) 6.62

Charge Density (pH 7.0) 0.0160

GRAVY Index0.12

Hydrophobic Moment 0.67

Boman Index0.15

Instability Index39.37

Aliphatic Index 100.29

Aromaticity 0.0807

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0238355 VERIFIED: NO

Provenance & Taxonomy

OrganismPanthera pardus (Leopard) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria