Peptide Database

Peptide NameFK 224

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length7 amino acids

Chemical FormulaC39H56N8O13

DescriptionStandard

        TYLFTNS
    

Molecular Weight844.91 Da

Isoelectric Point (pI)5.18

Net Charge (pH 7.0)-0.60

Net Charge (pH 7.4) -0.79

Charge Density (pH 7.0) -0.0861

GRAVY Index-0.06

Hydrophobic Moment 0.22

Boman Index0.21

Instability Index-12.90

Aliphatic Index 55.71

Aromaticity 0.2857

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 361.93

LogP -3.83

H-bond Donors 13.0

H-bond Acceptors 13.0

Rotatable Bonds 24.0

Heavy Atoms 60.0

Ring Count 2.0

Amide Bonds 7.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0380497 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsLactone bridge between threonine residue at position 1 and serine residue at position 7; tyrosine at position 2 is methylated; N-terminal threonine undergoes an undetermined modification

Bio-Activity Profile

Function

Receptor antagonist Signaling peptide

TargetNK1 receptor (Human); NK3 receptor (Human)