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MYP_084157
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Basic Information
As-CATH4
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
38 amino acids
C205H359N67O40
Standard
Sequence
RRGLFKKLRRKIKKGFKKIFKRLPPVGVGVSIPLAGRR
Physicochemical Analysis
4402.47 Da
12.00
14.75
14.54
0.3882
-0.49
0.94
-0.30
53.31
97.37
0.0789
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1775.34
-12.08
66.0
55.0
156.0
312.0
6.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0361514 VERIFIED: YES
Provenance & Taxonomy
Alligator sinensis [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Vibrio cholerae
2.13 μM
MIC
PMID29017942 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29017942/
RECORD: Rec_0369748 VERIFIED: YES
Provenance & Taxonomy
Alligator sinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial Antifungal Immunomodulatory Cytotoxic Anticancer Hemolytic Antimicrobial
Gram-negative and Gram-positive bacteria; Candida albicans; BGC-823 cells; human erythrocytes
MIC; cytotoxicity assay; hemolysis assay
PaperAs-CATH4 experimental characterization in Alligator sinensis PMID28798159;29017942
RECORD: Rec_0414366 VERIFIED: NO
Provenance & Taxonomy
Alligator sinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 28798159 PMID28798159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28798159/
RECORD: Rec_0420635 VERIFIED: YES
Provenance & Taxonomy
Alligator sinensis [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Vibrio harveyi
2.13 μM
MIC
PMID29017942 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29017942/
RECORD: Rec_0421834 VERIFIED: NO
Provenance & Taxonomy
Alligator sinensis [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Immunomodulatory
Escherichia coli, Shigella dysenteriae, Klebsiella pneumoniae, Klebsiella oxytoca, Proteus vulgaris, Proteus mirabilis, Acinetobacter baumannii, Stenotrophomonas maltophilia
PaperAs-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. PMID28798159
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