Peptide Database

Peptide NameW9F,T14A (mutant of Def-DAA defensin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC183H287N61O50S6

DescriptionStandard

        ATCDLASKFNWNHALCAAHCIARRYRGGYCNSKAVCVCR
    

Molecular Weight4334.01 Da

Isoelectric Point (pI)9.15

Net Charge (pH 7.0)4.91

Net Charge (pH 7.4) 4.52

Charge Density (pH 7.0) 0.1258

GRAVY Index-0.05

Hydrophobic Moment 0.52

Boman Index-0.06

Instability Index18.31

Aliphatic Index 62.82

Aromaticity 0.1026

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1809.63

LogP -21.18

H-bond Donors 72.0

H-bond Acceptors 63.0

Rotatable Bonds 138.0

Heavy Atoms 300.0

Ring Count 7.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064637 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetStaphylococcus aureus strain 21

Activity2-4 μg/mL

MethodIC90

RECORD: Rec_0120657 VERIFIED: YES