Peptide Database

Peptide NameLAK160-P10

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC130H233N33O25

DescriptionStandard

        KKLKLALAKPALLWKALALKLKKA
    

Molecular Weight2658.45 Da

Isoelectric Point (pI)10.85

Net Charge (pH 7.0)7.75

Net Charge (pH 7.4) 7.54

Charge Density (pH 7.0) 0.3230

GRAVY Index0.31

Hydrophobic Moment 0.42

Boman Index0.05

Instability Index3.11

Aliphatic Index 155.00

Aromaticity 0.0417

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 947.78

LogP -0.70

H-bond Donors 33.0

H-bond Acceptors 33.0

Rotatable Bonds 96.0

Heavy Atoms 188.0

Ring Count 3.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0359748 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative Antiplasmodial

TargetEscherichia coli NCTC 9001

Activity2.22±0.63 μM

MethodMIC

PaperConformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic alpha-helical peptides. J Biol Chem. 2012 Oct 5;287(41):34120-34133. doi: 10.1074/jbc.M112.359067. PMID: 22869378. PMID22869378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22869378/

RECORD: Rec_0417305 VERIFIED: YES