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MYP_084101
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Basic Information
D2A21
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition ▸ Release inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C144H212N32O24
Standard
Sequence
FAKKFAKKFKKFAKKFAKFAFAF
Physicochemical Analysis
2775.42 Da
10.90
8.75
8.53
0.3805
-0.08
0.83
-0.01
3.03
26.09
0.3478
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
937.70
-0.71
33.0
33.0
97.0
200.0
8.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0388781 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK / Hecate / Shiva peptide family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
BMKC
140.0 μg/mL
LD50 / MTT-MTS assay
PaperPMID 11751108; PMID 12707542; D2A21/Demegal clinical and preclinical reports PMID11751108;12707542 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11751108/ PatentUS_06875744_B2
RECORD: Rec_0393378 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
FLAK peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
H-1299
77 μg/mL
LD50
PaperShort bioactive peptides Evidence URLhttps://patents.google.com/patent/US6875744B2/en PatentUS6875744B2
RECORD: Rec_0394428 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic AMP
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial
Chlamydia trachomatis (2% D2A21 gel formulation)
700 μg/mL
MCC
PaperIn Vitro Microbicidal Activities of Cecropin Peptides D2A21 and D4E1 and Gel Formulations Containing 0.1 to 2% D2A21 against Chlamydia trachomatis.Antimicrob. Agents Chemother(2002) PMID11751108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11751108/
RECORD: Rec_0394869 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 2592
PMID11751108;32204024 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11751108/
RECORD: Rec_0403393 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Human cervical carcinoma HeLa
16.9 μg/mL
PMID11751108;32204024 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11751108/
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