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MYP_084054
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Basic Information
Esculentin-1ARb (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
46 amino acids
C226H381N59O61S3
Standard
Sequence
GLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC
Physicochemical Analysis
4997.00 Da
9.57
4.74
4.49
0.1031
0.03
0.68
0.05
12.97
95.22
0.0652
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1950.39
-14.91
69.0
69.0
178.0
349.0
4.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0194050 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
60 μM
MIC
PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
RECORD: Rec_0210593 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial Antiviral
Escherichia coli
3 μM
MIC
PaperAntimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata.
RECORD: Rec_0226933 VERIFIED: YES
Provenance & Taxonomy
Lithobates areolatus [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
60.0 μM
MIC
PaperM.F. Ali et al. / Biochimica et Biophysica Acta 1601 (2002) 55-63. Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata
RECORD: Rec_0239373 VERIFIED: YES
Provenance & Taxonomy
Lithobates areolatus [Animal]
225904
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
T cells
35 %
Inhibition
PaperAntimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. PMID16140737 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16140737/
RECORD: Rec_0243671 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
3 μM
MIC
PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
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