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MYP_084054
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Basic Information
Esculentin-1ARb (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
46 amino acids
C226H381N59O61S3
Standard
Sequence
GLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC
Physicochemical Analysis
4997.00 Da
9.57
4.74
4.49
0.1031
0.03
0.68
0.05
12.97
95.22
0.0652
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1950.39
-14.91
69.0
69.0
178.0
349.0
4.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028849 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
3 μM
MIC
PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
RECORD: Rec_0086256 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial Antiviral
but not Candida albicans
>200 μM
MIC
PaperAntimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata.
RECORD: Rec_0086467 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
120 μM
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/12429503/ PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
RECORD: Rec_0130540 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
60 μM
MIC
PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
RECORD: Rec_0148068 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
40-46
Bio-Activity Profile
Antimicrobial Antiviral
Staphylococcus aureus
60 μM
MIC
PaperAntimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata.
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