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MYP_083985
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Basic Information
Cycloviolacin O13
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C133H215N37O39S6
Standard
Sequence
GIPCGESCVWIPCISAAIGCSCKSKVCYRN
Physicochemical Analysis
3148.74 Da
8.33
1.70
1.40
0.0567
0.53
0.28
0.19
18.66
78.00
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1200.91
-13.62
48.0
47.0
98.0
215.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0197037 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antiviral Insecticidal
PaperPubMed PMID: 16872274 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID16872274;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0204253 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0204387 VERIFIED: NO
Provenance & Taxonomy
Viola tricolor [Plant] [Plant]; Viola odorata [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0238904 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
97441
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20; Cys8 and Cys22; Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.32 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0239768 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal Antiviral Antiparasitic
B. cinerea
3 μM
MIC
PaperA novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. PMID16872274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
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