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MYP_083985
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Basic Information
Cycloviolacin O13
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C133H215N37O39S6
Standard
Sequence
GIPCGESCVWIPCISAAIGCSCKSKVCYRN
Physicochemical Analysis
3148.74 Da
8.33
1.70
1.40
0.0567
0.53
0.28
0.19
18.66
78.00
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1200.91
-13.62
48.0
47.0
98.0
215.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0133477 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antiviral Insecticidal Hemolytic
human type A red blood cells
PaperPubMed PMID: 16872274 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID16872274;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0143042 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal Antiviral Antiparasitic
C. utrechtense
6.25 μM
MIC
PaperA novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. PMID16872274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0164571 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Nematocidal Anthelmintic Antiviral Anti-HIV Hemolytic Enzymatic-digestion Antimicrobial Antibacterial Antifungal Antiparasitic
Trichostrongylus colubriformis
PaperPubMed PMID 1532834 | PubMed PMID 7168722 | PubMed PMID 7000000 PMID1532834;7168722;7000000;15328347;16872;27000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1532834/
RECORD: Rec_0172479 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal Antiviral Antiparasitic
plant fungi Fusarium oxysporum
12.5-25 μM
MIC
PaperA novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. PMID16872274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0172654 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antiparasitic Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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