Peptide Database

Peptide NamePegvisomant

Function Ontology

Anticancer

Antiviral

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length191 amino acids

Chemical FormulaC990H1532N262O300S7

DescriptionStandard

        FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
    

Molecular Weight22128.78 Da

Isoelectric Point (pI)5.27

Net Charge (pH 7.0)-4.98

Net Charge (pH 7.4) -5.45

Charge Density (pH 7.0) -0.0261

GRAVY Index-0.41

Hydrophobic Moment 0.68

Boman Index-0.04

Instability Index40.76

Aliphatic Index 83.72

Aromaticity 0.1152

Extinction Coeff. Reduced 17420.00

Extinction Coeff. Oxidized 17670.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 9147.67

LogP -109.52

H-bond Donors 317.0

H-bond Acceptors 305.0

Rotatable Bonds 704.0

Heavy Atoms 1559.0

Ring Count 34.0

Amide Bonds 212.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0419959 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyInsulin

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPhosphorylation, Lipidation

Bio-Activity Profile

Function

Antiviral Anticancer Hormone replacement

TargetCHO

Half-LifeWhen somatotropin was administered subcutaneously at the dose of 0.024 mg/kg or 3 IU/m

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