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MYP_083956
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Basic Information
Pegvisomant
Anticancer
Antiviral
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
191 amino acids
C990H1532N262O300S7
Standard
Sequence
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Physicochemical Analysis
22128.78 Da
5.27
-4.98
-5.45
-0.0261
-0.41
0.68
-0.04
40.76
83.72
0.1152
17420.00
17670.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
9147.67
-109.52
317.0
305.0
704.0
1559.0
34.0
212.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0297552 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Monoclonal antibody
32630
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
PEGylation
Bio-Activity Profile
Immunomodulatory Hormone replacement Enzyme replacement
CHO
6 days
Evidence URLhttps://patents.google.com/patent/CA2230492 PatentCA2230492
RECORD: Rec_0346808 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Escherichia coli [Bacterium]
Peptide/protein therapeutic
9606;562
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PaperPubMed-linked source references: PMID:2688; PMID:2903866; PMID:16702112; PMID:5675428 PMID2688;2903866;16702112;5675428 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2688/ PatentCA1326439;CA2252535;US5288703;US5849700;US5849704;US5898030;US6004297;US6152897;US6235004;US6899699
RECORD: Rec_0378162 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation, Lipidation
Bio-Activity Profile
Antiviral Anticancer Hormone replacement Enzyme replacement
CHO
When somatotropin was administered subcutaneously at the dose of 0.024 mg/kg or 3 IU/m
Patent8920383
RECORD: Rec_0393743 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation, Lipidation
Bio-Activity Profile
Antiviral Hormone replacement
CHO
When somatotropin was administered subcutaneously at the dose of 0.024 mg/kg or 3 IU/m
Patent5288703
RECORD: Rec_0416639 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
somatotropin/prolactin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
53-165; 182-189
106-Ser: Phosphoserine; 137-Gln: Deamidated glutamine; by deterioration; 150-Ser: Phosphoserine; 152-Asn: Deamidated asparagine; by deterioration
Bio-Activity Profile
Hormone somatotropin prolactin family Growth factor signaling
PaperPDB 1BP3 structural record; X-ray; 2.90 A; chain A; residues 1-191
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