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MYP_083956
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Basic Information
Pegvisomant
Anticancer
Antiviral
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
191 amino acids
C990H1532N262O300S7
Standard
Sequence
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Physicochemical Analysis
22128.78 Da
5.27
-4.98
-5.45
-0.0261
-0.41
0.68
-0.04
40.76
83.72
0.1152
17420.00
17670.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
9147.67
-109.52
317.0
305.0
704.0
1559.0
34.0
212.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019279 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Insulin
32630
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
PEGylation
Bio-Activity Profile
Hormone replacement Enzyme replacement
CHO
6 days
Evidence URLhttps://patents.google.com/patent/CA2102129 PatentCA2102129
RECORD: Rec_0249981 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Escherichia coli [Bacterium]
Insulin
9606;562
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement
21.1 (±5.1) minutes
Evidence URLhttps://patents.google.com/patent/CA1326439 PatentCA1326439;CA2252535
RECORD: Rec_0254070 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement
21.1 (±5.1) minutes
Evidence URLhttps://patents.google.com/patent/CA2252535 PatentCA2252535
RECORD: Rec_0274638 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
PEGylated growth hormone analog
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
noncanonical stereochemical or chemical modification [Modified]
PEGylation
Bio-Activity Profile
Endocrine Growth hormone receptor antagonist
6 d
PaperPubMed-linked source references: PMID:20444908; PMID:18778113; PMID:17207591; PMID:16311417; PMID:15134290; PMID:15006735; PMID:14499709; PMID:12200225; PMID:11932320 PMID20444908;18778113;17207591;16311417;15134290;15006735;14499709;12200225;11932320 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20444908/ PatentUS5350836
RECORD: Rec_0292625 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Peptide/protein therapeutic
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
PaperPubMed-linked source references: PMID:1496949 PMID1496949 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1496949/ PatentUS5288703
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