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MYP_083790
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
14 amino acids
C77H125N17O16S3
Standard
Sequence
FLLFPLMCKIQGKC
Physicochemical Analysis
1641.12 Da
8.90
1.74
1.50
0.1242
1.08
0.32
0.35
10.91
111.43
0.1429
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
527.96
-0.36
19.0
21.0
54.0
113.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0226508 VERIFIED: YES
Provenance & Taxonomy
Nanorana parkeri [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0243686 VERIFIED: YES
Provenance & Taxonomy
Nanorana parkeri [Animal]
Japonicin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
8-14
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
22.85 μM
MIC
PaperZ. Lu et al. / Biochimie 92 (2010) 475-481. Novel families of antimicrobial peptides with multiple functions from skin of Xizang plateau frog, Nanorana parkeri Evidence URLhttps://www.uniprot.org/uniprotkb/D0ES73/entry
RECORD: Rec_0277204 VERIFIED: YES
Provenance & Taxonomy
Nanorana parkeri [Animal]
Japonicin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
8-14
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
61.0 μM
MIC
PaperZ. Lu et al. / Biochimie 92 (2010) 475-481. Novel families of antimicrobial peptides with multiple functions from skin of Xizang plateau frog, Nanorana parkeri Evidence URLhttps://www.uniprot.org/uniprotkb/D0ES73/entry
RECORD: Rec_0295441 VERIFIED: NO
Provenance & Taxonomy
Xizang plateau [Animal]
Japonicin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0328730 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
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