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MYP_083761
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Basic Information
Polybia-MPI peptide
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
14 amino acids
C78H131N19O20
Standard
Sequence
IDWKKLLDAAKQIL
Physicochemical Analysis
1654.99 Da
8.50
0.76
0.55
0.0542
0.06
0.71
0.06
33.86
153.57
0.0714
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
653.16
-1.70
22.0
21.0
58.0
117.0
2.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0277556 VERIFIED: YES
Provenance & Taxonomy
Polybia paulista [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Pseudomonas aeruginosa
5 μM
MIC
PaperStructural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista
RECORD: Rec_0315761 VERIFIED: YES
Provenance & Taxonomy
Polybia paulista [Animal]
Mastoparan
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 15422
8 μg/mL
MIC
PMID16129513 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16129513/
RECORD: Rec_0354839 VERIFIED: YES
Provenance & Taxonomy
Polybia paulista [Animal]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
tethers Lys6 and Arg10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
18.8 μM
MIC
PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0381428 VERIFIED: YES
Provenance & Taxonomy
Polybia paulista [Animal]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
tethers Lys6 and Arg10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
75 μM
MIC
PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
RECORD: Rec_0385629 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polybia-MP1
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
2.4 μg/mL
MIC
PaperHuy X Luong, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity and stability of stapled helices of polybia-MP1. Arch Pharm Res. 2017 Dec;40(12):1414-1419. Epub 2017 Oct 26. PMID29075946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29075946/
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