Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length449 amino acids

Chemical FormulaC2238H3554N634O614S14

DescriptionStandard

        MWLCLLLLMAACVPATTSSPGIKGRVTRSALEYGRRFGLELLRSLLQKEHSVNLQGSYQAPLLGRLNYTVPQIHIHELQMNDSTVDFAEDVGVQLTVHRARIQLSATWQAQLGAWQDSGSLRLRIRDLAVAVLLGLGADEHGHPSMWAAGCDARGTDLRLEFRQGQSWLYNLLVPLLQRTLRQQLNKQLCVEIQKGISRLQDSLKDVQVSAQLDPFAAIDLSLLGQPAITKQHGDVGLKGEFFGVHGRWQSPFSAQPVRLPELQEPMLLVAVTEFVANTAAFVYFTAGALRRNITAEMEHFPSRPVELHLWARRQPLLSCHPNALHGALFGSAEAFVVLPNATRVPAFLLNIDANVTGKPTIAGNRLGGTVGLRSLSVVQVMSHVGPLEVGKLENMLKFGLWLFGVPWANKRLRPGIPLPTPHGITLLHPRLSLHEGFMLITTDLHYEP
    

Molecular Weight49614.95 Da

Isoelectric Point (pI)9.14

Net Charge (pH 7.0)6.99

Net Charge (pH 7.4) 5.77

Charge Density (pH 7.0) 0.0156

GRAVY Index0.04

Hydrophobic Moment 0.79

Boman Index0.10

Instability Index50.47

Aliphatic Index 105.35

Aromaticity 0.0713

Extinction Coeff. Reduced 58440.00

Extinction Coeff. Oxidized 58690.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0320905 VERIFIED: NO

Provenance & Taxonomy

OrganismBambusicola thoracicus [Plant]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence