Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length142 amino acids

Chemical FormulaC716H1112N192O193S4

DescriptionStandard

        SSVSKKLESYLQTVPVTAKIDKVAGIDYSLVRPPVATAQSLKLALKGEFFSLARRTPFPFSAPALAFSPDPNRMLYFGVSSYFFNTAGFVYEAAGALVFNITNDMVRREGRLGGHAPWWLTLEGGLMRVPRSLFRGSMGKSR
    

Molecular Weight15625.92 Da

Isoelectric Point (pI)10.27

Net Charge (pH 7.0)8.55

Net Charge (pH 7.4) 8.27

Charge Density (pH 7.0) 0.0602

GRAVY Index0.02

Hydrophobic Moment 0.89

Boman Index0.09

Instability Index44.16

Aliphatic Index 81.76

Aromaticity 0.1268

Extinction Coeff. Reduced 18450.00

Extinction Coeff. Oxidized 18450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6122.04

LogP -55.83

H-bond Donors 217.0

H-bond Acceptors 207.0

Rotatable Bonds 500.0

Heavy Atoms 1105.0

Ring Count 31.0

Amide Bonds 147.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412413 VERIFIED: NO

Provenance & Taxonomy

OrganismSphenodon punctatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence