Peptide Database

Peptide NameP8

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC116H198N34O28

DescriptionStandard

        SYEIKINRHFKTLKKNLKKK
    

Molecular Weight2517.02 Da

Isoelectric Point (pI)10.47

Net Charge (pH 7.0)6.54

Net Charge (pH 7.4) 6.27

Charge Density (pH 7.0) 0.3271

GRAVY Index-1.45

Hydrophobic Moment 0.75

Boman Index-0.48

Instability Index-4.69

Aliphatic Index 78.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1073.11

LogP -7.89

H-bond Donors 38.0

H-bond Acceptors 36.0

Rotatable Bonds 94.0

Heavy Atoms 178.0

Ring Count 3.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0356672 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hemolytic

TargetMurine blood [HC10 = >640 microg/mL, HC50 = >640 microg/mL, Percent Hemolysis ± SD Hmax (100%) = 6.78 ± 2.4]

Activity640 μg/mL

MethodHC50

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