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MYP_083456
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Basic Information
Peptide-23
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GFXXGKXXGFXXGKXKKKK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0254168 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Tic- tetrahydroisoquinolinecarboxylic acid, Oic- octahydroindolecarboxylic acid
Bio-Activity Profile
Toxic Hemolytic Antibiotic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0259710 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Tic- tetrahydroisoquinolinecarboxylic acid, Oic- octahydroindolecarboxylic acid
Bio-Activity Profile
Antimicrobial Antibiotic
Mouse erythrocytes
25 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/17547385/ PMID17547385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
RECORD: Rec_0263490 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH-CH2-CH2-CH2-NH2, N terminal -acetyl at 3,7,11,15; non-canonical residue code at 4,8,12; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH-CH2-CH2-CH2-NH2, N terminal -acetyl
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtillis
PMID17547385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
RECORD: Rec_0296306 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Tic- tetrahydroisoquinolinecarboxylic acid, Oic- octahydroindolecarboxylic acid
Bio-Activity Profile
Antimicrobial Antibiotic
Mouse erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/17547385/ PMID17547385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
RECORD: Rec_0310404 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, f = D-phenylalanine, C terminal -CONH2, N terminal -acetyl at 3,7,11,15; non-canonical residue code at 4,8,12; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, f = D-phenylalanine, C terminal -CONH2, N terminal -acetyl
Bio-Activity Profile
Antimicrobial Antibacterial
MIC against Salmonella typhimurium
PMID17547385;23199484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
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