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MYP_083456
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Basic Information
Peptide-23
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GFXXGKXXGFXXGKXKKKK
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0223273 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial Immunomodulatory
Mycobacterium ranae (ATCC 110)
10 μM
MIC
PMID17547385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
RECORD: Rec_0246225 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH2, N terminal -acetyl at 3,7,11,15; non-canonical residue code at 4,8,12; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH2, N terminal -acetyl
Bio-Activity Profile
Antimicrobial Antibacterial
Brucella melitensis 16M
Qualitative functional evidence
PMID17547385;23199484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
RECORD: Rec_0351818 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH2, N terminal -acetyl at 3,7,11,15; non-canonical residue code at 4,8,12; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH2, N terminal -acetyl
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis
Qualitative functional evidence
PMID17547385;23199484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17547385/
RECORD: Rec_0375644 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
non-canonical residue code at 3,4,7,8,11,12; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH2, N terminal -acetyl at 15; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH2, N terminal -acetyl
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae BAMC 07-18
Qualitative functional evidence
PMID23199484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23199484/
RECORD: Rec_0394586 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
non-canonical residue code at 3,4,7,8,11,12; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH2, N terminal -acetyl at 15; tetrahydroisoquinolinecarboxylic acid, B = octahydroindolecarboxylic acid, C terminal -CONH2, N terminal -acetyl
Bio-Activity Profile
Antimicrobial Antibacterial
Acinetobacter baumannii WRAIR 13
Qualitative functional evidence
PMID23199484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23199484/
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