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MYP_083453
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Basic Information
Bombinin H-BO
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C77H138N18O18
Standard
Sequence
IIGPVLGLIGKALGGLL
Physicochemical Analysis
1604.03 Da
8.75
0.76
0.55
0.0447
1.82
0.43
0.72
23.01
206.47
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
546.15
-1.01
18.0
19.0
53.0
113.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0403117 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
256 μg/mL
MIC
PMID28636781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28636781/
RECORD: Rec_0403667 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Oriental fire-bellied toad,Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: Bombinin H-BO was found to lyse 38% of erythrocytes at concentration of 80
PaperPubMed PMID: 28636781 PMID28636781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28636781/
RECORD: Rec_0418758 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
1024 μg/mL
MIC
PMID28636781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28636781/
RECORD: Rec_0420820 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Oriental fire-bellied toad,Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
85% at the concentration of 159
85 %
Hemolysis
PaperPubMed PMID: 28636781 PMID28636781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28636781/
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