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MYP_083453
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Basic Information
Bombinin H-BO
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C77H138N18O18
Standard
Sequence
IIGPVLGLIGKALGGLL
Physicochemical Analysis
1604.03 Da
8.75
0.76
0.55
0.0447
1.82
0.43
0.72
23.01
206.47
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
546.15
-1.01
18.0
19.0
53.0
113.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0207632 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Oriental fire-bellied toad,Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 28636781 PMID28636781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28636781/
RECORD: Rec_0209683 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
16 μg/mL
MIC
RECORD: Rec_0229726 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Oriental fire-bellied toad,Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
SK-HEP-1
0.99 μM
IC50
PaperPubMed PMID: 28636781 PMID28636781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28636781/
RECORD: Rec_0242544 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0295194 VERIFIED: YES
Provenance & Taxonomy
skin secretion of Oriental fire-bellied toad,Bombina orientalis [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Hep-G2
2.88 μM
IC50
PaperPubMed PMID: 28636781 PMID28636781 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28636781/
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