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MYP_083352
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Basic Information
Dermal antimicrobial peptide Hs-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
20 amino acids
C104H170N22O26
Standard
Sequence
FLPLILPSIVTALSSFLKQG
Physicochemical Analysis
2144.59 Da
8.75
0.76
0.55
0.0380
1.27
0.54
0.50
56.73
156.00
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
748.67
-3.51
25.0
27.0
67.0
152.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0132328 VERIFIED: YES
Provenance & Taxonomy
Boana semilineata [Animal]
2339192
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV
DENV2
125 μg/mL
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperThe antimicrobial peptide HS-1 inhibits dengue virus infection. | Monteiro JMC, Oliveira MD, Dias RS, Nacif-Marçal L, Feio RN, Ferreira SO, Oliveira LL, Silva CC, Paula SO. | Virology. 2018 Jan 15;514:79-87. | DOI:10.1016/j.virol.2017.11.009 | PMID:29153860 PMID29153860 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29153860/
RECORD: Rec_0223730 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas semilineatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Cronobacter sakazakii ATCC 29004
PMID25772860;29153860 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25772860/
RECORD: Rec_0306347 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas semilineatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028
PMID25772860;29153860 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25772860/
RECORD: Rec_0345121 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas semilineatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Listeria monocytogenes ATCC 7644
46.6 μM
MIC
PaperIdentification and characterization of an antimicrobial peptide of Hypsiboas semilineatus (Spix, 1824) (Amphibia, Hylidae).
RECORD: Rec_0345875 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas semilineatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Bacillus subtilis ATCC 23858
23.3 μM
MIC
PMID25772860;29153860 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25772860/
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