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MYP_083352
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Basic Information
Dermal antimicrobial peptide Hs-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
20 amino acids
C104H170N22O26
Standard
Sequence
FLPLILPSIVTALSSFLKQG
Physicochemical Analysis
2144.59 Da
8.75
0.76
0.55
0.0380
1.27
0.54
0.50
56.73
156.00
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
748.67
-3.51
25.0
27.0
67.0
152.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001178 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas semilineatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes (50% Hemolysis at 82 microM, Vero cells (50% Cell death at 31.25 microg/ml
82 μM
Hemolysis
PMID25772860;29153860 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25772860/
RECORD: Rec_0007165 VERIFIED: YES
Provenance & Taxonomy
Hypsiboas semilineatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Listeria monocytogenes ATCC 7644
46.6 μM
MIC
PMID25772860;29153860 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25772860/
RECORD: Rec_0009544 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0026173 VERIFIED: YES
Provenance & Taxonomy
Boana semilineata [Animal]
2339192
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV
DENV3
7.81 μg/mL
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperThe antimicrobial peptide HS-1 inhibits dengue virus infection. | Monteiro JMC, Oliveira MD, Dias RS, Nacif-Marçal L, Feio RN, Ferreira SO, Oliveira LL, Silva CC, Paula SO. | Virology. 2018 Jan 15;514:79-87. | DOI:10.1016/j.virol.2017.11.009 | PMID:29153860 PMID29153860 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29153860/
RECORD: Rec_0029417 VERIFIED: YES
Provenance & Taxonomy
Boana semilineata [Animal]
2339192
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV
DENV3
125 μg/mL
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperThe antimicrobial peptide HS-1 inhibits dengue virus infection. | Monteiro JMC, Oliveira MD, Dias RS, Nacif-Marçal L, Feio RN, Ferreira SO, Oliveira LL, Silva CC, Paula SO. | Virology. 2018 Jan 15;514:79-87. | DOI:10.1016/j.virol.2017.11.009 | PMID:29153860 PMID29153860 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29153860/
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