Peptide Database

Peptide NameStripe

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC105H200N30O22

DescriptionStandard

        KLLKKAGKLLKKAGKLLKKAG
    

Molecular Weight2234.90 Da

Isoelectric Point (pI)10.90

Net Charge (pH 7.0)8.75

Net Charge (pH 7.4) 8.53

Charge Density (pH 7.0) 0.4167

GRAVY Index-0.39

Hydrophobic Moment 0.80

Boman Index-0.18

Instability Index-22.82

Aliphatic Index 125.71

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 879.50

LogP -4.51

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 89.0

Heavy Atoms 157.0

Ring Count 0.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0405558 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermNone

Other ModsThe Ⓩ (position: 13) in sequence denotes (R)-(7-octenyl)alanine. The Ⓧ (position: 20) in sequence denotes (S)-(4-pentenyl)alanine. Ⓩ (13) and Ⓧ (20) are cross-linked by side-stapling through a undec-4-enyl staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetmultidrug-resistant Pseudomonas aeruginosa ATCCBAA-2111 (MDRP)

Activity25 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling. Chempluschem. 2020 Dec;85(12):2731-2736. doi: 10.1002/cplu.202000749. PMID33369262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33369262/

RECORD: Rec_0422679 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas aeruginosa NBRC 13275

Activity1.56 μM

MethodMIC

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