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MYP_083337
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Basic Information
Stripe
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
21 amino acids
C105H200N30O22
Standard
Sequence
KLLKKAGKLLKKAGKLLKKAG
Physicochemical Analysis
2234.90 Da
10.90
8.75
8.53
0.4167
-0.39
0.80
-0.18
-22.82
125.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
879.50
-4.51
31.0
31.0
89.0
157.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0197074 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: Staphylococcus aureus NBRC13276
12.5 μM
MIC
PMID33369262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33369262/
RECORD: Rec_0206074 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
1.56 μM
MIC
PMID31303986;35073324 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31303986/
RECORD: Rec_0295114 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
The Ⓩ (position: 13) in sequence denotes (R)-(7-octenyl)alanine. The Ⓧ (position: 20) in sequence denotes (S)-(4-pentenyl)alanine. Ⓩ (13) and Ⓧ (20) are cross-linked by side-stapling through a undec-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa NBRC13275
50 μM
MIC
PaperMotoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling. Chempluschem. 2020 Dec;85(12):2731-2736. doi: 10.1002/cplu.202000749. PMID33369262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33369262/
RECORD: Rec_0298136 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
12.5 μM
MIC
PMID31303986;35073324 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31303986/
RECORD: Rec_0329680 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID33369262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33369262/
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