‹ ›
MYP_083337
← PREVIOUS NEXT → BACK
Basic Information
Stripe
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
21 amino acids
C105H200N30O22
Standard
Sequence
KLLKKAGKLLKKAGKLLKKAG
Physicochemical Analysis
2234.90 Da
10.90
8.75
8.53
0.4167
-0.39
0.80
-0.18
-22.82
125.71
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
879.50
-4.51
31.0
31.0
89.0
157.0
0.0
20.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0057353 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa NBRC13275
3.125 μM
MIC
PMID33369262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33369262/
RECORD: Rec_0076328 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
The Ⓩ (position: 6) in sequence denotes (R)-(7-octenyl)alanine. The Ⓧ (position: 13) in sequence denotes (S)-(4-pentenyl)alanine. Ⓩ (6) and Ⓧ (13) are cross-linked by side-stapling through a undec-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus NBRC13276
25 μM
MIC
PaperMotoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling. Chempluschem. 2020 Dec;85(12):2731-2736. doi: 10.1002/cplu.202000749. PMID33369262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33369262/
RECORD: Rec_0076652 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli DH5
3.125 μM
MIC
PMID31303986;35073324 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31303986/
RECORD: Rec_0085235 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
The Ⓩ (position: 6) in sequence denotes (R)-(7-octenyl)alanine. The Ⓧ (position: 13) in sequence denotes (S)-(4-pentenyl)alanine. Ⓩ (6) and Ⓧ (13) are cross-linked by side-stapling through a undec-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa NBRC13275
12.5 μM
MIC
PaperMotoharu Hirano, Chihiro Saito, Chihiro Goto, Hidetomo Yokoo, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Rational Design of Helix-Stabilized Antimicrobial Peptide Foldamers Containing α,α-Disubstituted Amino Acids or Side-Chain Stapling. Chempluschem. 2020 Dec;85(12):2731-2736. doi: 10.1002/cplu.202000749. PMID33369262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33369262/
RECORD: Rec_0092363 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
[ Refer Pubmed ID 35073323: Mycoplasma pneumoniae ]
PMID31303986;35073324 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31303986/
1 2 3 ... 5 NEXT LAST
Showing 5 records on this page · Page 1 of 5