Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length420 amino acids

Chemical FormulaC2118H3327N561O604S15

DescriptionStandard

        LSQIDPFAQIDYSLVSSPAVFKSHINMDLKGTVYPVGNHTDPPFVPAPFGLPNKIDSMLYLGVSNYFLKSATLAYYRAGVFNITISKDLATAFNLTTAILQDFVPEIALHCQTACPVLLKLTATSPPVVNLQSDTCGLWITGSVEVFAVLPNSTIQYIFTGNLRVPRHLFIRLKVIQLSQPCRDLNDTDDKEAIRAVLSLHSGNKYQRQFDSNQTEADHLNTSEEAPVLPAALCCWLLSGLTGGEFSVLHFKEGSDPNNQCLLSVQLKANPGLKVRITQKGLEYAKKVGVEILKENMEQEQFPDLIGYERFGLGNVHYNISRIRVTAVEFPNVSISLIPRSGVKLVIRNASLTINMNWNIRTWMFFLHDFFIKYLKKPIHRRLAANSCPNIRSGIQMIAKDFQSLNGESPVMSFLSASDL
    

Molecular Weight46794.44 Da

Isoelectric Point (pI)8.35

Net Charge (pH 7.0)3.59

Net Charge (pH 7.4) 2.67

Charge Density (pH 7.0) 0.0085

GRAVY Index0.02

Hydrophobic Moment 0.77

Boman Index0.11

Instability Index44.15

Aliphatic Index 99.57

Aromaticity 0.0929

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40380.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0279419 VERIFIED: NO

Provenance & Taxonomy

OrganismBambusicola thoracicus [Plant]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence