MYP_083305
stRRL
Antimicrobial
Antimicrobial
▸
Antibacterial
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Toxicity / Safety
▸
Cytotoxicity
Venom / Toxin
▸
General toxin
▸
Cytotoxicity
Standard
7 amino acids
C36H70N16O8
Standard
LARRLAR
855.04 Da
12.00
2.76
2.56
0.3943
-0.33
1.12
-0.60
90.40
140.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
423.62
-3.77
17.0
11.0
29.0
60.0
0.0
6.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0000760
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates S-(2,4)-pentenyl alanine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antimicrobial
Antibacterial
Escherichia coli 987P
4.00 μM
MIC
RECORD: Rec_0117029
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates S-(2,4)-pentenyl alanine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Cytotoxicity
murine macrophage cells (RAW264.7)
128 μM
Cell viability
RECORD: Rec_0133215
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates S-(2,4)-pentenyl alanine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Cytotoxicity
human embryonic kidney cells (HEK293T)
128 μM
Cytotoxicity
RECORD: Rec_0168060
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates S-(2,4)-pentenyl alanine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antimicrobial
Antibacterial
Salmonella typhimurium ATCC 14028
32.00 μM
MIC
RECORD: Rec_0198794
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates S-(2,4)-pentenyl alanine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Hemolytic
human red blood cells
>256 μM
MHC
Showing 5 records on this page · Page 1 of 2