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MYP_083304
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Basic Information
Ostricacin-2 (Beta-defensin 1)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
41 amino acids
C212H313N55O54S6
Standard
Sequence
APGNKAECEREKGYCGFLKCSFPFVVSGKCSRFFFCCKNIW
Physicochemical Analysis
4688.48 Da
8.89
3.74
3.45
0.0912
-0.08
0.45
0.03
45.40
38.05
0.1951
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1758.43
-15.03
67.0
64.0
151.0
327.0
11.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0211499 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Structure & Mods
disulfide-stabilized linear peptide [Linear]
canonical L-amino-acid peptide [L]
8-36; 15-30; 20-37
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
1.25 μg/mL
MIC
RECORD: Rec_0227755 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-36, 15-30, 20-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus 1056-MRSA
1.25 μg/mL
MIC
PMID16459058 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16459058/
RECORD: Rec_0253650 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli O157:H7
0.96 μg/mL
MIC
PaperIdentification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins.
RECORD: Rec_0295931 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0305371 VERIFIED: YES
Provenance & Taxonomy
Struthio camelus [Animal]
Beta-defensin; Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID16459058 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16459058/
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