Peptide Database

Peptide NameSP-10

Function Ontology

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Antiviral mechanism ▸ Pseudovirus inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC56H94N14O20S

DescriptionStandard

        STSQKSIVAYTM
    

Molecular Weight1315.49 Da

Isoelectric Point (pI)8.31

Net Charge (pH 7.0)0.46

Net Charge (pH 7.4) 0.25

Charge Density (pH 7.0) 0.0382

GRAVY Index-0.01

Hydrophobic Moment 0.16

Boman Index0.08

Instability Index11.07

Aliphatic Index 65.00

Aromaticity 0.0833

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 573.91

LogP -7.71

H-bond Donors 21.0

H-bond Acceptors 22.0

Rotatable Bonds 43.0

Heavy Atoms 91.0

Ring Count 1.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0026196 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilySynthetic antiviral peptide

Tax ID694009

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetSevere acute respiratory syndrome coronavirus

Activity0.00188 μM

MethodIC50

RECORD: Rec_0132595 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsContains non-standard symbols/residues: -.

Bio-Activity Profile

Function

Antiviral Anti-SARS-COV Pseudovirus inhibition

TargetSARS-CoV | Vero cells

Activity0.00188±0.00052 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperDesign and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. | Ho TY, Wu SL, Chen JC, Wei YC, Cheng SE, Chang YH, Liu HJ, Hsiang CY. | Antiviral Res. 2006 Feb;69(2):70-6. | DOI:10.1016/j.antiviral.2005.10.005 | PMID:16337697 PMID16337697 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16337697/