Peptide Database

Peptide Name2d (Atrial natriuretic peptide- Fc dimer)

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC173H275N61O55S4

DescriptionStandard

        SLRRSSCFGGRMDRIGAQSGLGCNSFRYGGSGGFCREGIN
    

Molecular Weight4217.67 Da

Isoelectric Point (pI)9.79

Net Charge (pH 7.0)3.43

Net Charge (pH 7.4) 3.18

Charge Density (pH 7.0) 0.0858

GRAVY Index-0.46

Hydrophobic Moment 0.60

Boman Index-0.12

Instability Index62.94

Aliphatic Index 41.50

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1915.10

LogP -29.07

H-bond Donors 74.0

H-bond Acceptors 63.0

Rotatable Bonds 143.0

Heavy Atoms 293.0

Ring Count 4.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0025140 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyNatriuretic peptide

Tax ID32630

Structure & Mods

Configbranched peptide architecture [Branched]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermFc region

Disulfide7-23

Other ModsComposite modified token region

Bio-Activity Profile

Function

Natriuretic Vasodilator

MethodELISA

Half-LifeFemale Wistar rats Plasma, in vivo; 10080 s